Piccolo regulates dopamine transporter internalization via PIP2
نویسندگان
چکیده
منابع مشابه
Membrane trafficking regulates the activity of the human dopamine transporter.
The trafficking of synaptic proteins is unquestionably a major determinant of the properties of synaptic transmission. Here, we present a detailed analysis of the downregulation and intracellular trafficking of the cocaine- and amphetamine-sensitive dopamine transporter (DAT), a presynaptic plasma membrane protein responsible for the regulation of extracellular DA concentrations. Using PC12 cel...
متن کاملVav2 regulates dopamine transporter-dependent mesolimbic dopamine homeostasis and behavioral responses to cocaine
Shuyong Zhu, Chengjiang Zhao, Yingying Wu, Qiaoqiao Yang, Aiyun Shao, Tiepeng Wang, Jianfu Wu, Yanqing Yin, Yandong Li, Jincan Hou, 1 Xinhua Zhang, 1,4 Guomin Zhou, Xiaosong Gu, Xiaomin Wang, Xosé R. Bustelo, Jiawei Zhou, 1 Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of ...
متن کاملIntracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter.
Although it is clear that amphetamine-induced dopamine (DA) release mediated by the dopamine transporter (DAT) is integral to the behavioral actions of this psychostimulant, the mechanism of this release is not clear. In this study, we explored the requirement for intracellular Ca(2+) in amphetamine-induced DA efflux and currents mediated by the human DAT. The patch-clamp technique in the whole...
متن کاملMitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity.
The dopamine transporter (DAT) regulates the clearance of dopamine (DA) released into the extracellular space and is an important site on which psychostimulants act to produce their effects. Here, we show that mitogen-activated protein kinase (MAPK) regulates the transport capacity and intracellular trafficking of DAT. Incubation of striatal synaptosomes or epitope-tagged human DAT (hDAT) human...
متن کاملIntracellular Ca Regulates Amphetamine-Induced Dopamine Efflux and Currents Mediated by the Human Dopamine Transporter
Although it is clear that amphetamine-induced dopamine (DA) release mediated by the dopamine transporter (DAT) is integral to the behavioral actions of this psychostimulant, the mechanism of this release is not clear. In this study, we explored the requirement for intracellular Ca in amphetamine-induced DA efflux and currents mediated by the human DAT. The patchclamp technique in the whole-cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2008
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2008.17